Possibilities with acceleration?

[LEGATO``]

So just yesterday I was backing out into the road and switched to drive, but I noticed that my acceleration was a tad bit off. A rather low sounding hum was coming from my engine and it didn't feel as if my car was accelerating despite the fact that the pedal was pressing down lightly. After driving around a bit, I noticed that as I drive in the neighborhoods it's just fine but as I go on the interstate when I actually have to accelerate a little harder, it makes the sound again and feels a little laggy.

Does anyone know what the problem is? I've checked google and whatnot and it's stating that it may be bad fuel mixture, spark plugs, and things of that nature.